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G9534

Sigma-Aldrich

Globotriaosylsphingosine from porcine blood

Synonym(s):

α-D-Gal-(1→4)-β-D-Gal-(1→4)-β-D-Glc-1→O-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C36H67NO17
CAS Number:
126550-86-5
Molecular Weight:
785.91
MDL number:
MFCD00675433
UNSPSC Code:
12352211
PubChem Substance ID:
24895378
NACRES:
NA.25

lipid type

sphingolipids

Quality Level

100

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCC\C=C\C(O)C(N)COC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(O)C3O)C(O)C2O)C(O)C1O

InChI

1S/C36H67NO17/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-21(41)20(37)19-49-34-30(47)27(44)32(23(17-39)51-34)54-36-31(48)28(45)33(24(18-40)52-36)53-35-29(46)26(43)25(42)22(16-38)50-35/h14-15,20-36,38-48H,2-13,16-19,37H2,1H3/b15-14+

InChI key

GRGNVOCPFLXGDQ-CCEZHUSRSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH1598V
MKCQ5619
MKCP9640
MKCK5219
MKCJ7828

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Tom G Obrig et al.
Current topics in microbiology and immunology, 357, 105-136 (2011-10-11)
The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D(+)HUS). The pathophysiology of renal disease in D(+)HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells
Ralf Krüger et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 883-884, 128-135 (2011-12-06)
Morbus Fabry is a hereditary metabolic disorder with low prevalence and late clinical manifestation. A defect in the α-galactosidase gene leads to lysosomal accumulation of the glycolipid globotriaosylceramide (Gb3). Gb3 may be used for monitoring of enzyme replacement therapy (ERT)
Early cerebral manifestations in a young female with Fabry disease with skewed X-inactivation.
M G Bouwman et al.
Clinical genetics, 80(5), 500-502 (2012-01-17)
Maria D Sanchez-Niño et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26(6), 1797-1802 (2010-05-28)
Transforming growth factor-β1 (TGF-β1) and the macrophage inhibitory factor receptor CD74 link the metabolic disorder with tissue injury in diabetic nephropathy. Fabry disease is an X-linked lysosomal glycosphingolipid storage disorder resulting from a deficient activity of α-galactosidase A that leads
S M Rombach et al.
Biochimica et biophysica acta, 1802(9), 741-748 (2010-05-18)
Fabry disease is an X-linked lysosomal storage disorder due to deficiency of alpha-Galactosidase A, causing accumulation of globotriaosylceramide and elevated plasma globotriaosylsphingosine (lysoGb3). The diagnostic value and clinical relevance of plasma lysoGb3 concentration was investigated. All male and adult female
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