Skip to Content
Merck
All Photos(2)

Key Documents

More Documents

SCC727

3dGRO® Colorectal Organoids (CSC.449N)

new

Synonym(s):

Colon Organoid, Colon Tumor Organoid, Colorectal Cancer Organoid, Human CRC Organoids

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

UNSPSC Code:
41106514

biological source

human

Quality Level

100

packaging

vial of ≥1500 organoids vial

manufacturer/tradename

Millipore

technique(s)

cell culture | mammalian: suitable
cell culture | stem cell: suitable

shipped in

liquid nitrogen

storage temp.

−196°C

Application

  • Viability: >1500 viable organoids/vial
  • Organoid Growth: Pass
  • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
  • Mycoplasma Contamination: Negative
  • STR Profile: Pass

Features and Benefits

Cryopreserved patient derived colorectal cancer organoids (PDOs)

Target description

Colorectal cancer accounts for roughly 10% of all cancer cases worldwide with more than half of all patients with CRC developing metastatic disease leading to death. Recently, tissue derived organoids have emerged as a more predictive 3 dimensional cell culture model of disease. 3D organoid cultures conserve the original genetic and phenotypic characteristics of the primary tissue allowing for their application in many research fields included drug development, personalized medicine and potential therapeutics. In vitro cultured tumor organoids have also been shown to predict patient response to chemotherapeutics. PDOs derived from colorectal cancer (CRC organoids) have been used for cell modeling and to investigate the function of cancer related driver gene mutations including APC, TP53, KRAS, BRAF, PIK3CA etc.

We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids from both normal and diseased patients derived from multiple regions of the digestive systems including small intestine (duodenum, ileum), stomach, rectum and colon.

Cell Line Characteristics
  • Sex: Male
  • Age: 40 Years
  • Organ: Colon
  • Disease: Normal (Adjacent Tissue to Tumor)

Storage and Stability

Store in liquid nitrogen. The organoids can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

3dGRO® is a trademark of KGaA, Darmstadt, Germany.3dGRO® organoids were derived utilizing HUB Organoid Technology.The purchaser of this product shall agree to HUB′s terms of use, which shall be separately acknowledged and accepted by such purchaser, prior to transfer of this product to purchaser.

Legal Information

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service