HAGE1MAG-20K

MILLIPLEX^® Human Aging Magnetic Bead Panel 1 - Metabolism Multiplex Assay

Properties

• species reactivity: human
• manufacturer/tradename: Milliplex^®
• technique(s): multiplexing: suitable
• detection method: fluorometric (Luminex^® xMAP^®)
• storage temp.: 2-8°C

Description

General description

Aging associated physiological changes and the pathological consequences of these changes make the elderly population vulnerable to many chronic diseases, including diabetes, cancers, cardiovascular and neurodegenerative diseases, etc. The complexity of the aging process has stimulated intensive research over the years. Aberrant glucose metabolism, elevated chronic inflammatory levels, progressive cellular senescence and other pathophysiological conditions have proven to be associated with the aging process.The MILLIPLEX^® MAP Human Aging Panel 1 covers multifaceted biomarkers of aging-related conditions. Monitoring these novel biomarkers would help researchers to understand the basic mechanisms that drive aging and eventually lead to improved clinical interventions for extending the human health span.The MILLIPLEX^® MAP Human Aging Panel 1 is an 10-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma, and in vitro samples: C-C motif chemokine 27 (CTACK/CCL27), Fibroblast growth factor 21 (FGF-21), Growth/differentiation factor 11 (GDF-11), Growth/differentiation factor 15 (GDF-15), Gonadoliberin (GnRH), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Interleukin 18 (IL-18), Jagged 1 protein (Jag1), and Leptin. Note: IL-10 is recommended for in vitro sample use only; do not test IL-10 in serum or plasma samples.

Specificity

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Application

For optimal sensitivity, use an overnight (16-18 hour) incubation. A two hour incubation can also be used. Serum and plasma samples require (recommend) a 1:2 dilution with Assay Buffer. Tissue culture supernatants may be run neat or appropriately diluted in control medium. Each well requires 25 μL of sample, standard or control. Analytes available:CTACK/CCL27, FGF-21, GDF-11, GDF-15, Gonadoliberin (GnRH), IL-6, IL-10, IL-18, Jagged 1 protein (Jag1), & Leptin

Features and Benefits

Configuration: Premixed

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS05,GHS07,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H302 + H312 + H332 - H317 - H318 - H373 - H411
• Precautionary Statements: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• Target Organs: Respiratory Tract
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3