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Key Documents

AB3000

Sigma-Aldrich

Anti-IP3 Receptor Type II Antibody

Chemicon®, from rabbit

Synonym(s):

Inositol 1,4,5-Trisphosphate Receptor

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50 μL
414,00 $

414,00 $

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50 μL
414,00 $

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

414,00 $

Please contact Customer Service for Availability
Request a Bulk Order

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, hamster, human, monkey, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_002223.2

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Anti-IP3 Receptor Type II Antibody Chemicon®, from rabbit

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Anti-ITPR3 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

HPA003915

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Anti-IP3R 1 from rabbit

ABS2129

Anti-IP3R 1

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

serum

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

species reactivity

mouse, hamster, human, monkey, rat

species reactivity

human, mouse

species reactivity

human

species reactivity

human, rat, bovine, mouse, chicken

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

ambient

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable, immunofluorescence: suitable, immunoprecipitation (IP): suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

immunohistochemistry: 1:200- 1:500

technique(s)

immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, western blot: suitable

Specificity

Rabbit anti-Type II Inositol 1,4,5-Trisphosphate Receptor (IP3R) is directed against a synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor. The antibody is reactive with Type II IP3R from rat, mouse, human, hamster, and monkey.

Immunogen

Synthetic peptide corresponding to the carboxy terminus of the rat Type II receptor

Application

Anti-IP3 Receptor Type II Antibody detects level of IP3 Receptor Type II & has been published & validated for use in IC, IF, IH, IP & WB.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Western blot: 1:50 - 1:100 (detects a 260 kDa band)

Immunofluorescence: 1:10 - 1:20

Immunoprecipitation

Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293, and RBL-2H3 cell lines.

Immunohistochemistry: Paraformaldehyde or methanol fixes are effective.

Optimal working dilutions must be determined by end user.

Physical form

Affinity purified versus immobilized immunogen peptide. Liquid in PBS buffer, containing 0.05% BSA, 10% glycerol, 0.005% sodium azide. Caution: Sodium azide is hazardous. MSDS available upon request.

Storage and Stability

Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

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    Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.
    Chen, R; Valencia, I; Zhong, F; McColl, KS; Roderick, HL; Bootman, MD; Berridge et al.
    The Journal of cell biology null
    Mark Chalmers et al.
    The Biochemical journal, 394(Pt 1), 57-66 (2005-11-09)
    The size and number of IP3R (inositol 1,4,5-trisphosphate receptor) clusters located on the surface of the ER (endoplasmic reticulum) is hypothesized to regulate the propagation of Ca2+ waves in cells, but the mechanisms by which the receptors cluster are not
    Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types.
    Wojcikiewicz, R J
    The Journal of Biological Chemistry, 270, 11678-11683 (1995)
    D I Yule et al.
    The Journal of biological chemistry, 272(14), 9093-9098 (1997-04-04)
    A key event leading to exocytosis of pancreatic acinar cell zymogen granules is the inositol 1,4,5-trisphosphate (InsP3)-mediated release of Ca2+ from intracellular stores. Studies using digital imaging microscopy and laser-scanning confocal microscopy have indicated that the initial release of Ca2+
    Takahiro Fujimoto et al.
    International journal of molecular medicine, 30(6), 1287-1293 (2012-09-21)
    KRAS-induced actin-interacting protein (KRAP), originally identified as one of the deregulated genes expressed in colorectal cancer, participates under physiological conditions in the regulation of systemic energy homeostasis and of the exocrine system. We have recently found that KRAP is a
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