AB2218
Anti-Aquaporin-4 Antibody
CHEMICON®, rabbit polyclonal
Synonym(s):
AQP4, WCH4, MIWC
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All Photos(3)
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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product name
Anti-Aquaporin 4 Antibody, Chemicon®, from rabbit
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... AQP4(361)
General description
The water-specific channel Aquaporin 4 is located in various tissues including the gastro intestinal tract, kidney and brain. It is an osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. The localization of AQ4 to astrocyte endfeet makes it an excellent marker for astrocyte distal processes.
Specificity
Recognizes Aquaporin 4.
The antibody has not yet been tested for cross-reactivity to other species. The immunogen shows 94% similarity to mouse, 88% to bovine, 86% to rabbit and 82% to human AQP4 (hAQP4).
Immunogen
Epitope: C-Terminus
Synthetic Linear Peptide
Application
Anti-Aquaporin 4 Antibody is an antibody against Aquaporin 4 for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western Blotting: 0.5-1 μg/mL using Chemiluminescence technique.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Target description
~34 kDa
Linkage
Replaces: AB3068
Physical form
ImmunoAffinity Purified
Purified in PBS with 0.05% NaN3
Storage and Stability
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
Analysis Note
Control
Tested on adult rat brain lysate
Tested on adult rat brain lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation.
Esther Steiner,Gaby U Enzmann,Shuo Lin,Sharang Ghavampour,Melanie-Jane Hannocks et al.
Glia null
Evidence of a rudimentary colon in the elasmobranch, Leucoraja erinacea.
Nicole Alexandra Theodosiou,Alyssa Simeone
Development Genes and Evolution null
Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis.
Karen Wolburg-Buchholz,Andreas F Mack,Esther Steiner,Friederike Pfeiffer et al.
Acta neuropathologica null
Absence of glial ?-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema.
Lien, CF; Mohanta, SK; Frontczak-Baniewicz, M; Swinny, JD; Zablocka, B; Gorecki, DC
The Journal of Biological Chemistry null
Stefanie Gurnik et al.
Acta neuropathologica, 131(5), 753-773 (2016-03-05)
The homeostasis of the central nervous system is maintained by the blood-brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signaling at the BBB
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