8.55052

Mca NovaTag^® resin

Novabiochem^®

• Synonym(s): N-Mca-NÆ-Fmoc-ethylenediamine MPB-AM resin

Properties

• Quality Level: 200
• product line: NovaSyn^® TG; Novabiochem^®
• form: beads
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: amine
• storage temp.: 15-25°C

Description

General description

Mca NovaTag resin is an ideal tool for the synthesis of FRET peptide substrates based on the 7-methoxycoumarin (Mca) and 2,4-dinitrophenyl(Dnp) fluorophore/quench pair. The resin pre-loaded with the Mca fluorophore can be used directly in Fmoc SPPS. Following peptide assembly, the Dnp group can be introduced using Fmoc-Lys(Dnp)-OH, to give after TFA cleavage the desired FRET peptide substrate.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Linkage

Replaces: 04-12-3902

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.20 - 0.50 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly styrene - 1 % DVB 100 - 200 mesh

Legal Information

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable