890899C

DODMA

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-Dioleyloxy-3-dimethylaminopropane
• Empirical Formula (Hill Notation): C₄₁H₈₁NO₂
• CAS Number: 104162-47-2
• Molecular Weight: 620.09
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: chloroform solution
• packaging: pkg of 1 × 4 mL (890899C-100MG); pkg of 5 × 4 mL (890899C-500MG)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• concentration: 25 mg/mL in chloroform
• application(s): advanced drug delivery
• lipid type: cationic lipids; transfection
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CN(C)CC(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC
• InChI: 1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3
• InChI key: GLGLUQVVDHRLQK-UHFFFAOYSA-N

Description

General description

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is an ionizable cationic lipid. DODMA possesses one double bond in each hydrocarbon tail with tertiary amine group and has a pKa of 7.0.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

Packaging

5 mL Clear Glass Sealed Ampule (890899C-100MG)
5 × 5 mL Clear Glass Sealed Ampule (890899C-500MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372
• Precautionary Statements: P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable