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840032P

Avanti

Brain PS

Avanti Research™ - A Croda Brand

Synonym(s):

L-α-phosphatidylserine (Brain, Porcine) (sodium salt)

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About This Item

CAS Number:
383907-32-2
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840032P-10mg)
pkg of 1 × 100 mg (840032P-100mg)
pkg of 5 × 100 mg (840032P-500mg)
pkg of 1 × 25 mg (840032P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C42H80NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h18,20,38-39H,3-17,19,21-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/b20-18-;/t38-,39+;/m1./s1

InChI key

ALPKKMIPHGSQRX-NJZWBUMZSA-M

Application

Brain PS has been used in lipid standard material preparation, reporter assay and in the preparation of liposomes.

Biochem/physiol Actions

Phosphatidylserine is a lipid. It helps to increase the cognitive performance of rats and humans, having different levels of age-dependent memory problems or probable Alzheimer disease. It has the ability to block degeneration of the cholinergic neuronal population of the basal forebrain of aged rats. 90% of the phosphatidylserine decarboxylase activity is linked with mitochondria.

Packaging

5 mL Clear Glass Sealed Ampule (840032P-100mg)
5 mL Clear Glass Sealed Ampule (840032P-10mg)
5 mL Clear Glass Sealed Ampule (840032P-25mg)
5 mL Clear Glass Sealed Ampule (840032P-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice
Claro FT, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30(5), 881-886 (2006)
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation
Song W, et al.
Alzheimers Dement., 13(4), 381-387 (2017)
Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology (2018)
Measurement of Binding of Basic Drugs to Acidic Phospholipids using Surface Plasmon Resonance and Incorporation of the Data into Mechanistic Tissue Composition Equations to Predict Steady-state Volume of Distribution (Vss)
Small H, et al.
Drug Metabolism and Disposition, dmd-111 (2011)
Characterization of brain phosphatidylserine decarboxylase: localization in the mitochondrial inner membrane
Percy AK, et al.
Archives of Biochemistry and Biophysics, 223(2), 484-494 (1983)
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