700042P

4β-hydroxycholesterol-d7

Avanti Polar Lipids

• Synonym(s): cholest-5-ene-3b,4b-diol(d7)
• Empirical Formula (Hill Notation): C₂₇H₃₉O₂D₇
• CAS Number: 1246302-80-6
• Molecular Weight: 409.70
• UNSPSC Code: 12352100
• NACRES: NA.25

Properties

• description: cholest-5-ene-3,4-diol-d7
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (700042P-1mg)
• manufacturer/tradename: Avanti Polar Lipids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3/t18-,19+,20-,21+,22+,24+,25-,26-,27-/m1/s1/i1D3,2D3,17D
• InChI key: CZDKQKOAHAICSF-BZNWTYAPSA-N

Description

General description

4β-hydroxycholesterol (4β-HC) is a catabolic product of cholesterol metabolism mediated by the enzyme cytochrome P450 family 3 subfamily A member 4 (CYP3A4). 4β-hydroxycholesterol-d7 is the deuterated form of 4β-hydroxycholesterol.

Application

4β-hydroxycholesterol-d7 has been used:

• as an internal standard to spike plasma samples ultra-high-pressure liquid,chromatography–tandem mass spectrometry (UHPLC-MS/MS) analysis
• to spike serum samples for mass spectrometry measurements
• as an internal standard for the quantification of human colon biopsies samples using HPLC-MS

Biochem/physiol Actions

4β-hydroxycholesterol (4β-HC) may function as a liver X receptor ligand. The levels of 4β-HC are elevated in dextran sulfate induced colitis along with other oxysterols and it may promote colon inflammation.

Packaging

5 mL Amber Glass Screw Cap Vial (700042P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids