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A2898

Sigma-Aldrich

4-Aminobiphenyl

≥98%

Synonym(s):

4-Aminodiphenyl, 4-Biphenylamine, 4-Biphenylylamine, 4-Phenylaniline, Biphenyl-4-ylamine, NSC 7660, Xenylamine

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About This Item

Linear Formula:
C6H5C6H4NH2
CAS Number:
92-67-1
Molecular Weight:
169.22
Beilstein:
386533
EC Number:
202-177-1
MDL number:
MFCD00007879
UNSPSC Code:
12352100
PubChem Substance ID:
57653839
NACRES:
NA.22

Quality Level

200

Assay

≥98%

form

solid

autoignition temp.

842 °F

bp

191 °C/15 mmHg (lit.)

mp

52-54 °C (lit.)

SMILES string

Nc1ccc(cc1)-c2ccccc2

InChI

1S/C12H11N/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,13H2

InChI key

DMVOXQPQNTYEKQ-UHFFFAOYSA-N

Gene Information

human ... UGT1A4(54657)

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Application

  • Induces DNA damage (carcinogen) in human bladder carcinoma cells and bladder tissue in mouse
  • Synthetic amine ligand for enrichment, depletion and one-step purification of leech proteins

Biochem/physiol Actions

Hepatic tumor initiator in experimental animal model.

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Danger

Hazard Statements

H302 - H350

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1A

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH SVHC Candidate List

CAS No.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K L Dooley et al.
Cancer letters, 62(3), 205-209 (1992-03-15)
The tumorigenic activities of four representative heterocyclic amine food pyrolysates, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5f]quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were assessed in the neonatal male B6C3F1 mouse and were compared with that of the potent human carcinogen, 4-amino-biphenyl (4-ABP). These
Dexian Dong et al.
Journal of molecular recognition : JMR, 21(3), 163-168 (2008-04-29)
Although the concept of affinity purification using synthetic ligands had been utilized for many years, there are few articles related to this research area, and they focus only on the affinity purification of specific protein by a defined library of
Samuel M Cohen et al.
Critical reviews in toxicology, 36(10), 803-819 (2006-11-23)
The IPCS Human Relevance Framework was evaluated for a DNA-reactive (genotoxic) carcinogen, 4-aminobiphenyl, based on a wealth of data in animals and humans. The mode of action involves metabolic activation by N-hydroxylation, followed by N-esterification leading to the formation of
Moinuddin et al.
Environmental toxicology, 29(5), 568-576 (2012-05-23)
4-Aminobiphenyl (4-ABP), an aromatic amine is a major environmental carcinogen found mainly in cigarette smoke. It has been vastly implicated in mutagenesis and cancer development. In this study, commercially available human placental DNA was exposed to 4-ABP (1.3 mM) in
Kristen L Randall et al.
Journal of chromatography. A, 1217(25), 4135-4143 (2009-11-26)
Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the bladder urothelium, leads to DNA adduct formation and cancer development [1]. Two major analytical challenges in DNA adduct analysis of human samples have been limited sample availability
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Articles

Carcinogenesis and Epigenetics

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Protocols

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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