910511
Pomalidomide-C6-PEG3-butyl alkyne
≥95.0%
Synonym(s):
N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-6-(2-(2-(oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanamide, Crosslinker–E3 Ligase ligand conjugate, Pomalidomide conjugate, Pomalidomide-6-2-2-6-alkyne, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader
About This Item
Assay
≥95.0%
form
(Liquid or Semi-solid or Paste or Solid)
reaction suitability
reaction type: click chemistry
reagent type: ligand-linker conjugate
functional group
alkyne
storage temp.
2-8°C
SMILES string
O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(CCCCCOCCOCCOCCCCCCC#C)=O)=O)NC1=O
Application
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Targeted Protein Degradation by Small Molecules
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
related product
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Articles
Partial PROTACs are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.
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