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367982

Sigma-Aldrich

2-Amino-5-fluorobenzoic acid

97%, for peptide synthesis

Synonym(s):

5-Fluoroanthranilic acid

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About This Item

Linear Formula:
H2NC6H3(F)CO2H
CAS Number:
446-08-2
Molecular Weight:
155.13
Beilstein:
2803664
EC Number:
207-159-7
MDL number:
MFCD00055566
UNSPSC Code:
12352106
PubChem Substance ID:
24862873
NACRES:
NA.22

product name

2-Amino-5-fluorobenzoic acid, 97%

Assay

97%

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

mp

181-183 °C (lit.)

application(s)

peptide synthesis

SMILES string

Nc1ccc(F)cc1C(O)=O

InChI

1S/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)

InChI key

FPQMGQZTBWIHDN-UHFFFAOYSA-N

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Application

Used in the synthesis of styrylquinazolinones which are potential anticancer agents.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCF9524
MKBX6889V
MKBS9392V
MKBR0207V
MKBK2663V

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J B Jiang et al.
Journal of medicinal chemistry, 33(6), 1721-1728 (1990-06-01)
A novel series of 2-styrylquinazolin-4(3H-ones which inhibited tubulin polymerization and the growth of L1210 murine leukemia cells was discovered. Extensive structure-activity relationship studies suggest that the entire quinazolinone structure was required, but activity was further enhanced by halide or small
João Daniel Santos Fernandes et al.
PloS one, 10(7), e0132369-e0132369 (2015-07-15)
Metabolic diversity is an important factor during microbial adaptation to different environments. Among metabolic processes, amino acid biosynthesis has been demonstrated to be relevant for survival for many microbial pathogens, whereas the association between pathogenesis and amino acid uptake and
Marcela Briones-Martin-del-Campo et al.
Microbiology (Reading, England), 161(Pt 2), 300-310 (2014-12-07)
The fungal pathogen Candida glabrata has a well-defined oxidative stress response, is extremely resistant to oxidative stress and can survive inside phagocytic cells. In order to further our understanding of the oxidative stress response in C. glabrata, we characterized the

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