SML2841

Tarenflurbil

≥98% (HPLC)

• Synonym(s): (R)-(−)-2-Fluoro-α-methyl-4-biphenylacetic acid, αR)-2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic acid, (-)-(R)-Flurbiprofen, (2R)-2-(3-Fluoro-4-phenylphenyl)propanoic acid, (R)-Flurbiprofen, Flurizan, R-flurbiprofen, (R)-2-Flurbiprofen, Tarenflurbil
• Linear Formula: C₆H₅C₆H₃(F)CH(CH₃)CO₂H
• CAS Number: 51543-40-9
• Molecular Weight: 244.26
• MDL number: MFCD00869714
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C[C@@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2
• InChI: 1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
• InChI key: SYTBZMRGLBWNTM-SNVBAGLBSA-N

Description

Biochem/physiol Actions

Tarenflurbil (or R-flurbiprofen) is an R enantiomer of racemic NSAID flurbiprofen that does not inhibit either cyclooxygenase 1 (COX-1) or cyclooxygenase 2 (COX-2). Tarenflurbil potently reduces levels of beta amyloid in human cells through direct inhibition of γ-secretase.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301 + H311 - H317 - H361d
• Precautionary Statements: P202 - P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Repr. 2 - Skin Sens. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable