SML1560

Azoramide

≥98% (HPLC)

• Synonym(s): N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]-butanamide, N-{2-[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]ethyl} butanamide
• Empirical Formula (Hill Notation): C₁₅H₁₇ClN₂OS
• CAS Number: 932986-18-0
• Molecular Weight: 308.83
• MDL number: MFCD08009374
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825964
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 30 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1
• InChI: 1S/C15H17ClN2OS/c1-2-3-14(19)17-9-8-13-10-20-15(18-13)11-4-6-12(16)7-5-11/h4-7,10H,2-3,8-9H2,1H3,(H,17,19)
• InChI key: VYBFWKKCWTXCQX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable