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S4447

Sigma-Aldrich

α-Synuclein E46K human

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

Synonym(s):

NACP (Non-a-beta component of Alzheimer disease amyloid, precursor), PARK1, PARK4, PD1, non A4 component of amyloid precursor

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

recombinant

expressed in E. coli

Quality Level

200

Assay

≥90% (SDS-PAGE)

form

lyophilized powder

mol wt

apparent mol wt 19-20 kDa

UniProt accession no.

P37840

compatibility

for use with ABI StepOnePlus

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SNCA(6622)

Biochem/physiol Actions

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran­sition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein.
Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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