N4663
Anti-Nurr1 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-NOT, Anti-NR4A2, Anti-Nuclear receptor of T cells, Anti-TINUR
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:200
western blot: 1:1,000-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NR4A2(4929)
mouse ... Pls3(18827)
rat ... Nr4a2(54278)
General description
Nur-related factor 1 (Nurr1) belongs to nuclear receptor super family. It is a brain-specific transcription factor, confined to central nervous system. Additionally, Nurr1 also modulates gene expression by repressing other transcriptional factors. Nurr1 is expressed in developing and mature dopamine neurons, hippocampus and cerebral cortex. It is crucial for the early development of dopamine neurons in midbrain during development, protection and survival of the neurons. Nurr1 may play a very critical role in the development of Parkinson′s disease and other neurodegenerative diseases and in human atherosclerotic lesions
Anti- Nurr1 recognizes human Nurr1.
Anti- Nurr1 recognizes human Nurr1.
Immunogen
synthetic peptide corresponding to an internal sequence of human Nurr1.
Application
Anti-Nurr 1 antibody may be used in immunoblotting at a working dilution of 1:1000 to 1:2000. For immunohistochemistry the recommended dilution is 1:100 to 1:200.
Physical form
Solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Asa Wallen-Mackenzie et al.
Genes & development, 17(24), 3036-3047 (2003-12-19)
The retinoid X receptor (RXR) is essential as a common heterodimerization partner of several nuclear receptors (NRs). However, its function as a bona fide receptor for endogenous ligands has remained poorly understood. Such a role would depend on the existence
S W Law et al.
Molecular endocrinology (Baltimore, Md.), 6(12), 2129-2135 (1992-12-01)
We have identified and cloned a novel member of the nuclear receptor superfamily. The cDNA was isolated from a mouse brain cDNA library and encodes a protein 598 amino acids in length with a predicted mol wt of 66 kilodaltons.
Banafsheh Kadkhodaei et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(50), 15923-15932 (2009-12-18)
Transcription factors involved in the specification and differentiation of neurons often continue to be expressed in the adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, is essential for early differentiation of midbrain
Peter I Bonta et al.
Circulation, 121(18), 2023-2032 (2010-04-28)
Restenosis is the major drawback of percutaneous coronary interventions involving excessive activation and proliferation of vascular smooth muscle cells (SMCs). The nuclear receptor Nurr1 is an early response gene known mainly for its critical role in the development of dopamine
Yinxiu Ding et al.
Molecular medicine reports, 14(3), 1993-1999 (2016-07-20)
Parkinson's disease (PD) is a severe neurodegenerative disorder. Although the detailed underlying molecular mechanism remains to be elucidated, the major pathological feature of PD is the loss of dopaminergic (DA) neurons of the substantia nigra. The use of donor stem
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