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Key Documents

MSQC8

Sigma-Aldrich

SigmaMAb Antibody Drug Conjugate (ADC) Mimic

Antibody Cysteine-Fluorophore Conjugate Standard

Synonym(s):

Antibody Drug Conjugate

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.32

recombinant

expressed in CHO cells

Quality Level

200

antibody product type

primary antibodies

form

lyophilized powder

shipped in

wet ice

storage temp.

−20°C

General description

SigmaMab Antibody Drug Conjugate (ADC) Mimic, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic conjugates SigmaMab (MSQC4), an IgG1 monoclonal antibody, to dansyl fluorophores via an LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC.

The ADC Mimic allows for safer and more consistent testing, making it the optimal product over real ADCs. It is also a more affordable product compared to real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

Application

Poster: Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Poster: LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

Poster: LC-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC Mimic

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK8647
SLCF8387
SLCF5047
SLCD2239
SLCC0520

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Protocols

Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk

LC-UV-MS Method Development for Antibody Drug Conjugates Using a Non-Toxic ADC-Mimic

SigmaMab Antibody Drug Conjugate Mimic, is a non-toxic drug mimic utilized as a standard for mass spectrometry and high performance liquid chromatography.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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