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Key Documents

GF319

Sigma-Aldrich

BMP-2, Human Recombinant
Animal Free

Synonym(s):

BMP2, BMP 2A, BMP 2, BMP2A, bone morphogenetic protein 2

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

Quality Level

UniProt accession no.

shipped in

dry ice

General description

BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with an osteoconductive carrier such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 appears to play an important role in cardiac morphogenesis, and is expressed in a variety of other tissues including lung, liver, spleen, prostate, ovary, and small intestine. Recombinant human BMP-2 is a 26.0 kDa homodimeric disulfide-linked protein consisting of two identical 115 amino acid chains.

Quality

Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 2


Certificates of Analysis (COA)

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