356780

Glycyrrhizin, Ammonium Salt

Inhibits replication, adsorption, and penetration of severe acute respiratory syndrome-associated coronavirus (SARS-CV). It is allso a known 11β-hydroxysteroid dehydrogenase type 2 (11-HSD2) inhibitor.

• Synonym(s): Glycyrrhizin, Ammonium Salt, Glycyrrhizic Acid, NH₄ ⁺
• Empirical Formula (Hill Notation): C₄₂H₆₁O₁₆ · NH₄
• CAS Number: 53956-04-0
• Molecular Weight: 839.96
• MDL number: MFCD00167400
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white to off-white
• solubility: aqueous NH₄OH: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54);1H3/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+;/m0./s1
• InChI key: ILRKKHJEINIICQ-OOFFSTKBSA-N

Description

General description

A triterpenoid saponin isolated from liquorice roots that displays antiviral and anti-tumor activities. Inhibits replication, adsorption, and penetration of severe acute respiratory syndrome-associated coronavirus (SARS-CV), presumably via its ability to upregulate nitric oxide synthase activity. Reported to block the growth of other viruses, including herpes virus, and helps restore liver functions in patients with hepatitis C. It is allso a known 11β-hydroxysteroid dehydrogenase type 2 (11-HSD2) inhibitor.

A triterpenoid saponin, isolated from liquorice roots, that exhibits anti-viral and anti-tumor activities. Inhibits replication, adsorption, and penetration of severe acute respiratory syndrome-associated coronavirus (SARS-CV), presumably as a result of its ability to upregulate nitric oxide synthase activity. Also reported to hamper the growth of other viruses, including herpes virus. Shown to restore liver function in patients with hepatitis C virus (HCV). Also shown to inhibit 11β-hydroxysteroid dehydrogenase type 2 (11-HSD2).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cinatl, J., et al. 2003. Lancet361, 2045.
Tanahashi, T., et al. 2002. J. Steroid Biochem. Mol. Biol.80, 441.
Kondo, Y., and Takano, F. 1994. Biol. Pharm. Bull.17, 759.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable