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791643C

Avanti

18:1-d7 Lyso PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-oleoyl(d7)-2-hydroxy-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C26H45D7NO7P
CAS Number:
2097561-13-0
Molecular Weight:
528.71
UNSPSC Code:
41141825
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (791643C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

1 mg/mL (791643C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

18:1-d7 Lyso PC 1-oleoyl(d7)-2-hydroxy-sn-glycero-3-phosphocholine is a deuterated phospholipid. The lipid lysophosphatidylcholine is esterified with oleic acid. Oleic acid harbors the deuterium ions. Lysophosphatidylcholine (LPC) is derived from phosphatidylcholine by the action of enzyme phospholipase A2.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH™ LIPIDOMIX™ Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.

Application

18:1-d7 Lyso PC has been used:
  • as an internal standard in high performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESIMS/MS) for the lipidomics analysis of bone marrow-derived macrophages
  • as a component of extraction solvent for lipid isolation from biological samples
  • as an internal standard for spiking serum samples for liquid chromatography with tandem mass spectrometry (LC-MS/MS)

Biochem/physiol Actions

Lysophosphatidylcholine (LPC). Elevated levels of LPC is associated with diabetes and cardiovascular diseases. LPC stimulates cytokines and is implicated in allergic disease. It also elicits lysis on membranes.

Packaging

5 mL Clear Glass Sealed Ampule (791643C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
LIPIDOMIX is a trademark of Avanti Polar Lipids, LLC
SPLASH is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shayne A Snider et al.
The Journal of biological chemistry, 293(29), 11600-11611 (2018-06-09)
Choline is an essential nutrient that is required for synthesis of the main eukaryote phospholipid, phosphatidylcholine. Macrophages are innate immune cells that survey and respond to danger and damage signals. Although it is well-known that energy metabolism can dictate macrophage
Michael S Gardner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119, 137-147 (2019-04-30)
Progress toward better diagnosis and treatment of lipid metabolism-related diseases requires high throughput approaches for multiplexed quantitative analysis of structurally diverse lipids, including phospholipids (PLs). This work demonstrates a simplified "one-pot" phospholipid extraction protocol, as an alternative to conventional liquid-liquid
Tong Liu et al.
Expert review of proteomics, 17(3), 233-242 (2020-04-21)
Background: Colorectal cancer (CRC) represents a third leading cause of cancer-related death worldwide. The reliable diagnostic biomarkers for detecting CRC at early stage is critical for decreasing the mortality.Method: A conjunctive lipidomic approach was employed to investigate the differences in
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using

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