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536822

Sigma-Aldrich

PAMAM-OH dendrimer, generation 6 solution

5 wt. % in methanol

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About This Item

Linear Formula:
[NH2(CH2)2NH2]:(G=6);dendri PAMAM(NHCH2CH2OH)256
Molecular Weight:
58298.21
MDL number:
MFCD00197936
UNSPSC Code:
12162002
NACRES:
NA.25

description

amidoethanol surface groups

Quality Level

100

form

liquid

mol wt

generation 6

feature

core type ethylenediamine core (2-carbon core)

concentration

5 wt. % in methanol

no. Surface Groups

256

refractive index

n20/D 1.336

density

0.807 g/mL at 25 °C

storage temp.

2-8°C

General description

PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.

Application

PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.

Physical form

Contains 256 surface hydroxyl groups.

Legal Information

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Certificates of Analysis (COA)

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Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)

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