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Sigma-Aldrich

Poly(ethylene oxide)

average Mv 100,000 (nominal), powder

Synonym(s):

Polyethylene oxide, PEO

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About This Item

Linear Formula:
(-CH2CH2O-)n
CAS Number:
25322-68-3
MDL number:
MFCD00081839
UNSPSC Code:
12352104
PubChem Substance ID:
24850968
NACRES:
NA.23

form

powder

Quality Level

200

mol wt

average Mv 100,000 (nominal)

contains

200-500 ppm BHT as inhibitor

refractive index

n20/D 1.4539

viscosity

12-50 cP, 5 % in H2O(25 °C, Brookfield)(lit.)

transition temp

Tg −67 °C
Tm 65 °C

density

1.13 g/mL at 25 °C

Ω-end

hydroxyl

α-end

hydroxyl

SMILES string

[H]OCCO

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Poly(ethylene oxide) is a non-ionic hydrophilic linear polymer. It can be prepared by catalytic polymerization of ethylene oxide. Owing to its hydration and swelling properties, it is widely used in controlled drug delivery systems and bioadhesive materials.

Application

PEO can be used to:
  • Prepare polymer brushes with unique wormlike conformation which can be used in cancer drug delivery systems.
  • Synthesize polymer electrolytes for solid-state batteries and fuel cells.
  • Prepare biodegradable PEO/Ag nanocomposites forbiomedical and food packaging applications.

Features and Benefits

  • High water solubility
  • Non-toxicity
  • Rapid hydration
  • Insensitive to pH of the physiological system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Wang, X.-L., et al.
Jiangsu Huagong, 32, 27-27 (2004)
Yeonsu Jung et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(3) (2021-01-13)
Mud nests built by swallows (Hirundinidae) and phoebes (Sayornis) are stable granular piles attached to cliffs, walls, or ceilings. Although these birds have been observed to mix saliva with incohesive mud granules, how such biopolymer solutions provide the nest with
Alexandre Goyon et al.
Electrophoresis, 39(16), 2083-2090 (2018-05-19)
The determination of mAb critical quality attributes (CQA) is crucial for their successful application in health diseases. A generic CZE method was developed for the high-resolution separation of various mAb charge variants, which are often recognized as important CQA. A
D D Smyth et al.
Cardiovascular drugs and therapy, 4(1), 297-300 (1990-02-01)
Previous studies have demonstrated that Separan AP-30, a drag-reducing polymer, significantly decreased the formation of atherosclerotic plaques in rabbits fed a high-cholesterol diet. Furthermore, Separan AP-273, a polymer similar to but longer than Separan AP-30, markedly increased cardiac output in
M Patel Geeta et al.
Current drug delivery, 6(2), 159-165 (2009-05-20)
Carbamazepine indicated for the control of epilepsy, undergoes extensive hepatic first-pass metabolism after oral administration. A vaginal dosage form of carbamazepine is not commercially available. Conventional suppository having poor retention in the vaginal tract, as they are removed in a
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Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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