1096586

Carglumic Acid

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): N-Carbamyl-L-glutamic acid
• Empirical Formula (Hill Notation): C₆H₁₀N₂O₅
• CAS Number: 1188-38-1
• Molecular Weight: 190.15
• MDL number: MFCD00047874
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749237
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• manufacturer/tradename: USP
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-8°C
• SMILES string: NC(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
• InChI key: LCQLHJZYVOQKHU-VKHMYHEASA-N
• Gene Information: human ... CPS1(1373)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Efficacy of Carglumic Acid in Nutritional Management of N-Acetylglutamate Synthase Deficiency: A study evaluated the effectiveness of Carglumic Acid in the nutritional management of patients with N-Acetylglutamate Synthase deficiency, showing significant improvements in patient outcomes (Singh et al., 2024).



• Real-World Use of Carglumic Acid for Organic Acidurias: An observational study highlighted the real-world application of Carglumic Acid in treating methylmalonic and propionic acidurias, demonstrating beneficial effects in metabolic management (Yap et al., 2024).



• Management of Hyperammonemia in Postpartum Women: Research documented a case of partial N-acetyl glutamate synthase deficiency presenting as postpartum hyperammonemia, with management strategies involving Carglumic Acid (Abou Haidar et al., 2023).



• Genetic Insights from Carglumic Acid Treatment: Research on novel compound heterozygote variants in the CPS1 gene emphasized the lessons learned from clinical management using Carglumic Acid, impacting late onset carbamoyl phosphate synthetase 1 deficiency (Lin et al., 2022).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable