18127

1,1,1,3,3,3-Hexafluoro-2-propanol

for LC-MS LiChropur^™

• Synonym(s): HFP, Hexafluoroisopropanol
• Linear Formula: (CF₃)₂CHOH
• CAS Number: 920-66-1
• Molecular Weight: 168.04
• Beilstein: 1841007
• MDL number: MFCD00011651
• UNSPSC Code: 12352104

Properties

• Assay: ≥99.8% (GC)
• form: liquid
• quality: for LC-MS LiChropur^™
• impurities: ≤0.02% water
• refractive index: n20/D 1.275 (lit.)
• bp: 59 °C (lit.)
• mp: −4 °C (lit.)
• density: 1.596 g/mL at 25 °C (lit.)
• cation traces: Al: ≤0.5 ppm; Ca: ≤0.5 ppm; Cu: ≤0.02 ppm; Fe: ≤0.1 ppm; K: ≤2 ppm; Mg: ≤0.1 ppm; Na: ≤10 ppm
• suitability: passes test for LC-MS (ESI/APCI pos. < 10 ppb)
• SMILES string: OC(C(F)(F)F)C(F)(F)F
• InChI: 1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
• InChI key: BYEAHWXPCBROCE-UHFFFAOYSA-N

Description

General description

1,1,1,3,3,3-Hexafluoro-2-propanol(HFIP) is a thermally stable, highly polar, UV-transparent solvent that is misciblewith water and many polar organic solvents. It is used as a mobile phaseadditive in liquid chromatography-mass spectrometry (LC-MS) method to improveseparation and detection.

Application

1,1,1,3,3,3-Hexafluoro-2-propanol can be used as a:

• Buffer additive for LC-ESI-MS to separate acidic and basic compounds.
• Eluent additive in the UHPLC-MS/MS method to improve the chromatographic separation of basic and zwitterionic compounds.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS08
• Signal Word: Danger
• Hazard Statements: H314 - H361 - H373
• Precautionary Statements: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2
• Storage Class Code: 8A - Combustible, corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): closed cup - boils before flash
• Flash Point(C): closed cup - boils before flash