T0656
1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril
Synonym(s):
Iodo-Gen®, NSC 4462
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About This Item
Empirical Formula (Hill Notation):
C16H10Cl4N4O2
CAS Number:
Molecular Weight:
432.09
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
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![6-Amino-2-[bis(carboxymethyl)amino]hexanoic acid](/deepweb/assets/sigmaaldrich/product/structures/296/586/23c9423a-18d4-4c77-a438-b818ddf93bef/640/23c9423a-18d4-4c77-a438-b818ddf93bef.png)
storage temp.
2-8°C
Quality Level
SMILES string
ClN1C(=O)N(Cl)C2(N(Cl)C(=O)N(Cl)C12c3ccccc3)c4ccccc4
InChI
1S/C16H10Cl4N4O2/c17-21-13(25)23(19)16(12-9-5-2-6-10-12)15(21,11-7-3-1-4-8-11)22(18)14(26)24(16)20/h1-10H
InChI key
FJQZXCPWAGYPSD-UHFFFAOYSA-N
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Related Categories
Application
Iodination reagent used in radioiodination acting as an oxidative agent
Reagent involved in comparison studies with chloramine-T
Reagent used for oxidation of urazoles
Reagent involved in comparison studies with chloramine-T
Reagent used for oxidation of urazoles
Legal Information
Iodo-Gen is a registered trademark of Pierce Biotechnology, Inc.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.
P J Fraker et al.
Biochemical and biophysical research communications, 80(4), 849-857 (1978-02-28)
Ganesan Vaidyanathan et al.
Nuclear medicine and biology, 29(1), 1-11 (2002-01-12)
Monoclonal antibodies (mAbs) such as the tumor-specific anti-epidermal growth factor receptor variant III (EGFRvIII) that are internalized and degraded after cell binding necessitate the use of radioiodination methods that minimize the loss of radioactivity from the tumor cell after intracellular
Ly Tran et al.
Cancer biotherapy & radiopharmaceuticals, 24(1), 103-110 (2009-02-27)
The aim of this study was to develop a safe and simple radiolabeling and purification procedure for high-dose (131)I-rituximab for treatment of patients with non-Hodgkin's lymphoma. As the starting point, the conventional Iodogen-coated vial method was applied. After the iodogen-coated
P K Garg et al.
Bioconjugate chemistry, 6(4), 493-501 (1995-07-01)
The F(ab')2 fragment of monoclonal antibody (MAb) Me1-14 was labeled with 125I using the Iodogen method and by reaction with N-succinimidyl 3-[125I]iodobenzoate (SIB). The labeled catabolites generated after exposure to tissue homogenates in vitro and following administration of labeled F(ab')2
Ying Xie et al.
Journal of pharmaceutical and biomedical analysis, 54(1), 148-153 (2010-09-11)
The aim of the present study was to characterize the preclinical pharmacokinetics, tissue distribution and excretion profiles of porcine fibrinogen in rats after intraperitoneal injection of a porcine-derived fibrin glue. A sensitive and rapid isotope-labeled assay method was developed and
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