SML3370

BI605906

≥98% (HPLC)

• Synonym(s): 3-Amino-4-(1,1-difluoro-propyl)-6-(4-methanesulfonyl-piperidin-1-yl)-thieno[2,3-b]pyridine-2-carboxylic acid amide, 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide, BI 605906, BI-605906
• Empirical Formula (Hill Notation): C₁₇H₂₂F₂N₄O₃S₂
• CAS Number: 960293-88-3
• Molecular Weight: 432.51
• MDL number: MFCD22665698
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: , White to very dark gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CCC(F)(C1=C2C(SC(C(N)=O)=C2N)=NC(N3CCC(CC3)S(C)(=O)=O)=C1)F

Description

Biochem/physiol Actions

BI605906 is a selective, ATP-competitive IκB kinase β (IKK2, IKKβ, IKK-beta) inhibitor (IC50 = 380 nM, [ATP] = 0.1 mM) with no potency toward 100 other kinases, including IKKα, IKKε, TBK1, and IGF1R (IC50 ≥7.6 µM). BI605906 (10 µM) effectively blocks IKK-β-dependent phosphorylation of IKKε and TBK1 in IKKα-/- MEFs upon IL-1α (5 ng/mL) induction.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable