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Key Documents

SML3284

Sigma-Aldrich

MS1943

≥98% (HPLC)

Synonym(s):

N-​[(1,​2-​Dihydro-​4,​6-​dimethyl-​2-​oxo-​3-​pyridinyl)​methyl]​-​1-​(1-​methylethyl)​-​6-​[6-​[4-​[2-​[(2-​tricyclo[3.3.1.13,​7]​dec-​1-​ylacetyl)​amino]​ethyl]​-​1-​piperazinyl]​-​3-​pyridinyl]​-1H-​indazole-​4-​carboxamide

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About This Item

Empirical Formula (Hill Notation):
C42H54N8O3
CAS Number:
2225938-17-8
Molecular Weight:
718.93
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

Biochem/physiol Actions

MS1943 is a potent and selective degrader of EZH2 (enhancer of zeste homolog 2) that effectively reduces EZH2 levels in cells. MS1943 potently inhibits growth of multiple TNBC cells and in mice xenograft model.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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