SML3099
Glyght
≥95% (HPLC)
Synonym(s):
(E)-5-Phenyl-7-(pyridin-2-yldiazenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
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About This Item
Empirical Formula (Hill Notation):
C20H15N5O
CAS Number:
Molecular Weight:
341.37
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder
storage condition
protect from light at room temperature
color
yellow to orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1NC(C=CC(/N=N/C2=NC=CC=C2)=C3)=C3C(C4=CC=CC=C4)=NC1
General description
Glyght is a benzodiazepine-containing azobenzene compound that acts as a light-controlled negative allosteric modulator that is selective to glycine receptors. It is a powerful and effective compound that can operate in vivo. Glyght attaches to an allosteric site within the interface between the extracellular and transmembrane domains. It is an effective tool for researchers since it has broad activity in both homo- and heteromeric GlyRs across several species of fish and mammals. Moreover, Glyght is photo-switchable at 365 nm for trans-cis isomerization and 455 to 530 nm for cis-trans isomerization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Alexandre M J Gomila et al.
Cell chemical biology, 27(11), 1425-1433 (2020-08-28)
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo
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