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SML2422

Sigma-Aldrich

Sophocarpine

≥95% (HPLC)

Synonym(s):

(-)-Sophocarpine, 13,14-Didehydromatridin-15-one, SC

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O
CAS Number:
6483-15-4
Molecular Weight:
246.35
MDL number:
MFCD00274555
UNSPSC Code:
12352200

biological source

Sophora alopecuroides

Assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -26 to -35°, c = 0.5 in ethanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1

InChI key

NBBQEIQEBNYSFK-PUILLJIJSA-N

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Biochem/physiol Actions

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Genhuan Yang et al.
Annals of palliative medicine, 9(4), 1622-1630 (2020-06-13)
Cigarette smoking is one of the main predisposing factors for atherosclerosis, which can lead to vascular inflammation. Emerging research has demonstrated that the rate of restenosis is increased following angioplasty in smokers. Sophocarpine, one of the Sophora alkaloids, can play

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