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Key Documents

SML1019

Sigma-Aldrich

Lofexidine hydrochloride

≥98% (HPLC)

Synonym(s):

2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole hydrochloride, Baq 168, Britlofex, Lofetensin, Loxacor, MDL 14042

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About This Item

Empirical Formula (Hill Notation):
C11H12Cl2N2O · HCl
CAS Number:
21498-08-8
Molecular Weight:
295.59
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H

InChI key

DWWHMKBNNNZGHF-UHFFFAOYSA-N

Biochem/physiol Actions

Lofexidine, a derivative of clonidine, is a very potent agonist of α2 adrenoceptors. Lofexidine is used as a treatment for withdrawl from heroin and other opiates, and as a short-activg anti-hypertensive agent.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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