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Key Documents

SML0922

Sigma-Aldrich

NSC130813

≥98% (HPLC)

Synonym(s):

4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02

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About This Item

Empirical Formula (Hill Notation):
C26H27ClN4O2 · 3HCl
CAS Number:
1082532-95-3
Molecular Weight:
572.35
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

H2O: 10 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.

Other Notes

air sensitive

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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