SAB4502691
Anti-S6K antibody produced in rabbit
affinity isolated antibody
Synonym(s):
70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, S6K, S6K1, p70 S6 kinase α
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All Photos(2)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 59 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RPS6KB1(6198)
General description
Ribosomal protein S6 kinase B1 (RPS6KB1) also known as S6Ka or S6K1 is an isoform of S6 kinases, which belong to AGC serine/threonine kinases of the ribosomal S6 kinase (RSK) family. S6K1 is encoded by the gene mapped to human chromosome 17q23. S6K1 is activated on phosphorylation of its domains, which include T-loop and hydrophobic motif and Ser-Pro/Thr-Pro residues at C- terminal.
Immunogen
The antiserum was produced against synthesized peptide derived from human S6K.
Immunogen Range: 261-310
Immunogen Range: 261-310
Biochem/physiol Actions
Ribosomal protein S6 kinase B1 (RPS6KB1), or S6K1, regulates cell size and progression through cell cycle. It also inhibits pro-apoptotic protein bcl-2-associated death promoter (BAD) and promotes cell survival. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1, mTORC1-S6K1 complex regulates various cellular processes, such as transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. Overexpression of S6 kinase 1 (S6K1) leads to many disorders , including diabetes, aging, and cancer. Development of organometallic S6K1 inhibitors such as EM5 and FL772, might be a potential method for the treatment of diseases caused by aberrant activity of S6K1. The increased expression of S6K1 in obesity results in adipose tissue dysfunction via a close association with insulin resistance and inflammation development. Elevated expression of S6K1 is observed in breast cancer patients.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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R M Biondi et al.
The EMBO journal, 20(16), 4380-4390 (2001-08-14)
PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3-kinase-dependent manner in response to insulin/growth factors signalling. Activation entails phosphorylation of these kinases at two residues, the T-loop and the hydrophobic motif. PDK1 activates S6K, SGK and
Brian Magnuson et al.
The Biochemical journal, 441(1), 1-21 (2011-12-16)
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating
F J Couch et al.
Cancer research, 59(7), 1408-1411 (1999-04-10)
The application of comparative genomic hybridization to the analysis of genetic abnormalities in breast carcinoma has consistently revealed that chromosome region 17q22-24 is a frequent site of gene amplification in this type of cancer. As part of an examination of
Andrea R Marti et al.
Frontiers in neural circuits, 11, 70-70 (2017-11-01)
Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. Disturbed circadian rhythmicity resulting from night shift work
Jie Qin et al.
Journal of medicinal chemistry, 58(1), 305-314 (2014-10-31)
Aberrant activation of S6 kinase 1 (S6K1) is found in many diseases, including diabetes, aging, and cancer. We developed ATP competitive organometallic kinase inhibitors, EM5 and FL772, which are inspired by the structure of the pan-kinase inhibitor staurosporine, to specifically
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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