SAB3500383

Anti-CXCR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-CXCR4
• MDL number: MFCD01092337
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human
• technique(s): flow cytometry: suitable; immunocytochemistry: suitable; immunofluorescence: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_003458
• UniProt accession no.: P61073
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CXCR4(7852)

Description

General description

C-X-C motif chemokine receptor 4 (CXCR4) is encoded by the gene mapped to human chromosome 2q22.1. The gene codes for a protein with seven transmembrane regions. The encoded protein is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells.

Immunogen

CXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.

Application

Anti-CXCR4 antibody produced in rabbit has been used in western blot analysis and indirect ELISA.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

C-X-C motif chemokine receptor 4 (CXCR4) is specific for stromal cell-derived factor-1. It plays a vital role in regulation of immune response in various immune cell types. CXCR4 interacts with CD4 (cluster of differentiation 4) and permits human immunodeficiency virus type 1 (HIV-1) entry and infection in to the cells. Polymorphism in the gene is associated with the development of Juvenile idiopathic arthritis (JIA). In addition, mutation in the gene increases the risk of susceptibility to cardiovascular diseases (CVDs).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500383.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable