P5556
Poloxamer 188 solution
10%, sterile-filtered, BioReagent, suitable for insect cell culture
Synonym(s):
Nonionic copolymer surfactant
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12161902
PubChem Substance ID:
NACRES:
NA.75
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description
non-ionic
Quality Level
sterility
sterile-filtered
product line
BioReagent
mol wt
average mol wt 8350
concentration
10%
technique(s)
cell culture | insect: suitable
impurities
endotoxin, tested
CMC
0.04 mM
transition temp
cloud point ≥100
HLB
29
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
General description
Poloxamer 188 (P188) is a non-ionic amphiphilic copolymer. It comprises a central chain of hydrophobic polyoxypropylene flanked at ends by hydrophilic polyoxyethylene.
Application
A nonionic copolymer surfactant
Biochem/physiol Actions
Poloxamer 188 (P188) elicits hemorheological, antithrombotic, anti-inflammatory, and cytoprotective activities. It restores and stabilizes membrane barrier function. P188 also inhibits lipid peroxidation, reduces surface tension and hydrophobic-based cellular adherence. P-188 exhibits low toxicity and may be used in oral drug delivery.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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