P0113

PQ401

≥98% (HPLC), powder

• Synonym(s): IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
• Empirical Formula (Hill Notation): C₁₈H₁₆ClN₃O₂
• CAS Number: 196868-63-0
• Molecular Weight: 341.79
• MDL number: MFCD00160558
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724567
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23
• InChI: 1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
• InChI key: YBLWOZUPHDKFOT-UHFFFAOYSA-N

Description

Application

PQ401 has been used as:

• an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression
• a reference inhibitor in dose-response measurements studies
• an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition

Biochem/physiol Actions

PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.

PQ401, a diaryl urea compound that serves as an anti-glioma agent.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves