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L9037

Sigma-Aldrich

L-Lysine monohydrate

BioReagent, suitable for cell culture, from non-animal source

Synonym(s):

L-Lysine hydrate (1:1), Lysine monohydrate

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About This Item

Empirical Formula (Hill Notation):
C6H14N2O2 · H2O
CAS Number:
39665-12-8
Molecular Weight:
164.20
Beilstein:
4349963
EC Number:
200-294-2
MDL number:
MFCD00151035
UNSPSC Code:
12352209
PubChem Substance ID:
24896515

biological source

non-animal source

Quality Level

300

product line

BioReagent

Assay

98.5-101.5% dry basis

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

215 °C

solubility

H2O: soluble

SMILES string

[H]O[H].NCCCC[C@H](N)C(O)=O

InChI

1S/C6H14N2O2.H2O/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H2/t5-;/m0./s1

InChI key

HZRUTVAFDWTKGD-JEDNCBNOSA-N

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General description

L-Lysine is an amino acid with a basic side chain and is amphipathic in nature. It has a protonated alkyl amino group and is fully protonated at physiological pH. L-lysine mainly participates in electrostatic interactions in proteins.

Application

L-Lysine monohydrate has been used in:
  • SILAC (stable isotope labeling by amino acids in cell culture) method
  • the complete synthetic (C) medium for positive selection screening of yeast cells
  • the growth medium for cells

Biochem/physiol Actions

L-Lysine is an essential proteinogenic α amino acid used in a wide range of applications including as a non-animal sourced supplement in cell culture media, a substrate of enzymes such as L-lysine oxidase (EC 1.4.3.14), a component of poly-lysine polymers, and a substrate for oxidation and glycation mechanism studies.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shao-En Ong et al.
Nature protocols, 1(6), 2650-2660 (2007-04-05)
Stable isotope labeling by amino acids in cell culture (SILAC) is a simple, robust, yet powerful approach in mass spectrometry (MS)-based quantitative proteomics. SILAC labels cellular proteomes through normal metabolic processes, incorporating non-radioactive, stable isotope-containing amino acids in newly synthesized
Daniel Kalb et al.
Chembiochem : a European journal of chemical biology, 16(10), 1426-1430 (2015-05-13)
L-α-Aminoadipic acid reductases catalyze the ATP- and NADPH-dependent reduction of L-α-aminoadipic acid to the corresponding 6-semialdehyde during fungal L-lysine biosynthesis. These reductases resemble peptide synthetases with regard to their multidomain composition but feature a unique domain of elusive function--now referred
Harvey RA, et al.
Biochemistry (Lippincott's illustrated reviews) (2011)
W L McKeehan et al.
Proceedings of the National Academy of Sciences of the United States of America, 73(6), 2023-2027 (1976-06-01)
The trace element selenium is essential for clonal growth of diploid fibroblasts from human fetal lung (WI-38) in media containing small amounts of serum protein. Maximum growth stimulation is obtained when 30 nM neutralized selenious acid is added to a
Garrett RH and Grisham CM
Biochemistry (2016)
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