L7659

Lewis-b tetrasaccharide

• Synonym(s): α-Fuc(1→2)-β-Gal-(1→3)-(α-Fuc-[1→4])-GlcNAc, Le^b glycan
• Empirical Formula (Hill Notation): C₂₆H₄₅NO₁₉
• Molecular Weight: 675.63
• MDL number: MFCD01632618
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817653
• NACRES: NA.32

Properties

• storage temp.: −20°C
• SMILES string: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]2O[C@@H]3[C@@H](NC(C)=O)C(O)O[C@H](CO)[C@H]3O[C@@H]4O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]4O)[C@@H](O)[C@H](O)[C@@H]1O
• InChI: 1S/C26H45NO19/c1-6-12(31)15(34)18(37)24(40-6)44-20-10(5-29)42-23(39)11(27-8(3)30)21(20)45-26-22(17(36)14(33)9(4-28)43-26)46-25-19(38)16(35)13(32)7(2)41-25/h6-7,9-26,28-29,31-39H,4-5H2,1-3H3,(H,27,30)/t6-,7-,9+,10+,11+,12+,13+,14-,15+,16+,17-,18-,19-,20+,21+,22+,23?,24-,25-,26-/m0/s1
• InChI key: OXNGKCPRVRBHPO-VIXGDSECSA-N

Description

General description

The Lewis b (Leb) antigens are widely expressed in the proximal colon. During fetal development, Leb antigens are found throughout the colon, but after birth, they gradually diminish in the distal colon.

Application

Lewis-b tetrasaccharide has been used to treat the P protein for complex crystal growth.

Biochem/physiol Actions

The Lewis b (Leb) antigen reappearance is an excellent tumor marker for discriminating between malignant and benign tumors, and it can also be used in many cases of colon cancer.

Other Notes

Lewis-b human blood group determinant.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves