G0668

GW2974

≥98% (HPLC), solid

• Synonym(s): N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine
• Empirical Formula (Hill Notation): C₂₃H₂₁N₇
• CAS Number: 202272-68-2
• Molecular Weight: 395.46
• MDL number: MFCD04974495
• UNSPSC Code: 51111800
• PubChem Substance ID: 24278451
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: DMSO: ≥20 mg/mL
• originator: GlaxoSmithKline
• SMILES string: CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1
• InChI: 1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)
• InChI key: DYYZXRCFCVDSKD-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956) , ERBB2(2064)

Description

Biochem/physiol Actions

Potent and selective dual inhibitor of EGFR (IC₅₀ = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves