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E1631

Sigma-Aldrich

β-Estradiol 17-valerate

≥98% (HPLC), powder

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 17-pentanote

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About This Item

Empirical Formula (Hill Notation):
C23H32O3
CAS Number:
979-32-8
Molecular Weight:
356.50
Beilstein:
2480357
EC Number:
213-559-2
MDL number:
MFCD00056541
UNSPSC Code:
41116107
PubChem Substance ID:
24894423
NACRES:
NA.77

product name

β-Estradiol 17-valerate, ≥98%

biological source

synthetic

Quality Level

100

Assay

≥98%

form

powder

technique(s)

ELISA: suitable

solubility

acetone: 25 mg/mL, hazy, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C

InChI

1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3

InChI key

RSEPBGGWRJCQGY-UHFFFAOYSA-N

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General description

β-Estradiol 17-valerate is a synthetic estrogen.

Application

β-Estradiol 17-valerate has been used:
  • in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
  • to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
  • to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model

Biochem/physiol Actions

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Warning

Hazard Statements

H351,H361fd,H362,H410

Hazard Classifications

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Huib A A M Van Vliet et al.
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Reproductive biomedicine online, 24(3), 272-280 (2012-02-03)
This randomized controlled trial analyses the ability to control the oocyte retrieval schedule of gonadotrophin-releasing hormone antagonist cycles through the administration of oestradiol valerate during the luteo-follicular transition period prior to the initiation of ovarian stimulation. Eighty-six women undergoing ovarian
Stephen M Junk et al.
Fertility and sterility, 98(4), 888-892 (2012-07-28)
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Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder with a high prevalence of hypertension and cardiovascular disease. Because SLE predominantly affects women, estrogen is commonly implicated as a contributor to SLE disease progression. Using an established mouse model
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