B8686

(+)-N-3-Benzylnirvanol

≥98% (HPLC), powder, CYP2C19 inhibitor

• Synonym(s): (5S)-5-Ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione, 5-Ethyl-5-phenyl-3-(phenylmethyl)hydantoin
• Empirical Formula (Hill Notation): C₁₈H₁₈N₂O₂
• CAS Number: 790676-40-3
• Molecular Weight: 294.35
• MDL number: MFCD09840024
• UNSPSC Code: 12161501
• PubChem Substance ID: 329773138
• NACRES: NA.77

Properties

• product name: (+)-N-3-Benzylnirvanol, ≥98% (HPLC), powder
• Assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >20 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CC[C@]1(NC(=O)N(Cc2ccccc2)C1=O)c3ccccc3
• InChI: 1S/C18H18N2O2/c1-2-18(15-11-7-4-8-12-15)16(21)20(17(22)19-18)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3,(H,19,22)/t18-/m0/s1
• InChI key: ZMZDHUHMXXALFX-SFHVURJKSA-N

Description

Application

(+)-N-3-Benzylnirvanol may be used as a cytochrome P450 2C19 (CYP2C19) inhibitor in a comparison study to treat cocktail and individual substrates for the screening for potent cytochrome P450 (CYP) inhibition. It may also be used in comparative studies to investigate its potential as CYP and non-CYP selective inhibitors of CYP2C19 in suspended human hepatocytes.

Biochem/physiol Actions

(+)-N-3-Benzyl-nirvanol is a potent selective CYP2C19 inhibitor. CYP2C19 has a high frequency of drug resistance; highly polymorphic.

(+)-N-3-Benzylnirvanol serves as an inhibitor of cytochrome P450 2B6 (CYP2B6).

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H319,H400
• Precautionary Statements: P264 - P270 - P273 - P280 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves