B3501

Betaine hydrochloride

≥99%

• Synonym(s): (Carboxymethyl)trimethylammonium hydrochloride
• Linear Formula: (CH₃)₃N⁺CH₂COOH · Cl^-
• CAS Number: 590-46-5
• Molecular Weight: 153.61
• Beilstein: 3916181
• EC Number: 209-683-1
• MDL number: MFCD00011903
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278266
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Assay: ≥99%
• form: powder or crystals
• mp: 241-242 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: room temp
• SMILES string: [Cl-].C[N+](C)(C)CC(O)=O
• InChI: 1S/C5H11NO2.ClH/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H
• InChI key: HOPSCVCBEOCPJZ-UHFFFAOYSA-N
• Gene Information: human ... BHMT(635) , BHMT2(23743)

Description

General description

Betaine (trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in from choline. Betaine is usually present in grains, spinach, beets, broccoli, shellfish and marine algae.

Application

Betaine hydrochloride has been used as a component of fixative in HEPES or cacodylate buffer to improve preservation of the ultrastructural morphology of human spermatozoa.

Biochem/physiol Actions

Betaine hydrochloride can decrease hepatotoxicity, that is stimulated by ethanol.

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves