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Y0000537

Emedastine difumarate

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C25H34N4O9
CAS Number:
87233-62-3
Molecular Weight:
534.56
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

emedastine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C17H26N4O.2C4H4O4/c1-3-22-14-13-21-16-8-5-4-7-15(16)18-17(21)20-10-6-9-19(2)11-12-20;2*5-3(6)1-2-4(7)8/h4-5,7-8H,3,6,9-14H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+

InChI key

FWLKKPKZQYVAFR-LVEZLNDCSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Emedastine difumarate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Ryoichi Morita et al.
Journal of controlled release : official journal of the Controlled Release Society, 90(1), 109-117 (2003-05-28)
In vitro dissolution tests of novel controlled release tablets, the poly(vinyl alcohol) (PVA) swelling controlled release system (SCRS), were performed by various methods under different conditions in the sinking state in water. The in vitro release profiles of various tests
Shoichi Harada et al.
Drug metabolism and pharmacokinetics, 20(5), 331-336 (2005-11-08)
In vivo percutaneous absorption of emedastine difumarate was investigated in rats and compared with rat skin in vitro. Since emedastine entering the systemic circulation is mostly excreted in bile, we first came up with the method of collecting bile with
Mark B Abelson et al.
Clinical therapeutics, 24(3), 445-456 (2002-04-16)
When selecting treatment for allergic conjunctivitis, a primary concern is whether to choose local or systemic therapy. This study compared the efficacy of topical emedastine 0.05% ophthalmic solution with that of oral loratadine 10 mg and their combination in the
M Eugenia Sanchis-Merino et al.
Experimental eye research, 86(5), 791-797 (2008-04-02)
In order to compare the relative efficacy of topical antihistamines with balanced saline solution (BSS) and benzalkonium chloride (BC) in the early phase of allergic conjunctivitis in an animal model of ocular anaphylaxis, 96 male guinea pigs were sensitized with
P Haicl et al.
Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 60(1), 58-63 (2004-03-12)
To determine, whether the immediately originated allergic reaction of conjunctivas may be treated with local H1 antihistaminic drugs in a monotherapy (Allergodil gtt, Emadine gtt). The group included 30 patients at the age of 17 to 40 years at the
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