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Key Documents

MAB3564

Sigma-Aldrich

Anti-Sodium/Iodine Symporter Antibody, a.a. 625-643, clone FP5A

clone FP5A, Chemicon®, from mouse

Synonym(s):

Na+/I- Symporter, NIS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

FP5A, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_000453.1

UniProt accession no.

Q92911

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC5A5(6528)

Specificity

Sodium/Iodide Symporter (NIS). The epitope is thought to be in the region of amino acids 625-643 of human NIS. The antibody may show some reactivity to Maltose Binding Protein.

Immunogen

Epitope: a.a. 625-643
Maltose Binding Protein fusion protein corresponding to amino acids 468-643 of human NIS (C-terminus).

Application

Detect Sodium/Iodine Symporter using this Anti-Sodium/Iodine Symporter Antibody, a.a. 625-643, clone FP5A validated for use in IH, IH(P) & WB.
Immunoblotting. The antibody recognizes a major band at ~97 kDa and minor bands at 15 kDa, 30 kDa, 68 kDa and 160 kDa.

Immunohistochemistry. The antibody works on paraffin embedded tissue sections which have been subjected to antigen retrieval with 10 mM citrate buffer steam for 30 minutes.

Optimal working dilutions must be determined by end user.

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Use of sodium iodide symporter expression in differentiated thyroid carcinomas.
Elaine C Morari,Marjory A Marcello,Ana Carolina T Guilhen,Lucas L Cunha,Paulo Latuff et al.
Clinical Endocrinology null
Christina Schug et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(19), 5997-6008 (2019-06-15)
The innate tumor homing potential of mesenchymal stem cells (MSCs) has been used for a targeted delivery of the theranostic sodium iodide symporter (NIS) transgene into solid tumors. We have previously shown that external beam radiotherapy (EBRT) results in the
M R Castro et al.
The Journal of clinical endocrinology and metabolism, 84(8), 2957-2962 (1999-08-12)
The thyroid sodium-iodide symporter (NIS) is responsible for iodide concentrating ability within thyroid follicular cells. We sought to develop monoclonal antibodies against human NIS (hNIS) for use as reagents in structure-function studies of the protein, as well as potential tools

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