AB1255
Anti-Cytochrome P450 Enzyme CYP1A1 and CYP1A2 Antibody
serum, Chemicon®
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... AHRR(57491)
Specificity
Reacts with rat cytochrome P450 enzyme CYP1A1 and CYP1A2 on Western blots of hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes.
Immunogen
Synthetic peptide
Application
Detect Cytochrome P450 Enzyme CYP1A1 & CYP1A2 using this Anti-Cytochrome P450 Enzyme CYP1A1 & CYP1A2 Antibody validated for use in ELISA & WB.
Research Category
Metabolism
Metabolism
Research Sub Category
Enzymes & Biochemistry
Enzymes & Biochemistry
Western blot: useful for the simultaneous detection of rat CYP1A1 (57 kDa) and CYP1A2 (54 kDa), which can be separated electrophoretically.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Physical form
Rabbit antiserum. Liquid. Contains no preservative.
Storage and Stability
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Analysis Note
Control
POSITIVE CONTROL: rat hepatic microsomal fraction.
POSITIVE CONTROL: rat hepatic microsomal fraction.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Identification of the epitope of an anti-peptide antibody which binds to CYP1A2 in many species including man
Edwards, R J, et al
Biochemical Pharmacology, 46, 213-220 (1993)
Synthetic peptide antigens elicit monoclonal and polyclonal antibodies to cytochrome P450 IA2.
Myers, M J, et al.
Biochemical and biophysical research communications, 169, 171-176 (1990)
Stephanie E Martinez et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(11), 1314-1324 (2019-08-21)
Dogs are commonly used in human and veterinary pharmaceutical development. Physiologically based pharmacokinetic modeling using recombinant cytochrome P450 (CYP) enzymes requires accurate estimates of CYP abundance, particularly in liver. However, such estimates are currently available for only seven CYPs, which
A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells.
Yoshida, Y; Shimomura, T; Sakabe, T; Ishii, K; Gonda, K; Matsuoka, S; Watanabe, Y; Takubo et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology null
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