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900130E

Avanti

13(S)HODE

Avanti Polar Lipids (900130E), ethanol solution

Synonym(s):

13S-Hydroxy-9Z,11E-octadecanoic acid

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About This Item

Empirical Formula (Hill Notation):
C18H32O3
CAS Number:
29623-28-7
Molecular Weight:
296.44
UNSPSC Code:
12352211

Assay

99% (TLC)

form

ethanol solution

packaging

pkg of 1 × 1 mg (900130E-1mg)
pkg of 1 × 500 μg (900130E-500ug)

manufacturer/tradename

Avanti Polar Lipids (900130E)

concentration

1 mg/mL (900130E-1MG)
500 μg/mL (900130E-500UG)

lipid type

neutral glycerides
neutral lipids

shipped in

dry ice

storage temp.

−70°C

General description

13-S-hydroxyoctadecadienoic acid (13(S)HODE) is a metabolite of 15-lipoxygenase (15-LOX). It is an endogenous ligand of peroxisome proliferator-activated receptorγ (PPARγ).

Biochem/physiol Actions

13-S-hydroxyoctadecadienoic acid (13(S)HODE) inhibits cell proliferation and induces apoptosis in many human cancers. It also enhances the activity of nuclear factor κ light chain enhancer of activated B cells (NF-κB) in keratinocytes.

Packaging

2ml Amber Glass Sealed Ampule

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225 - H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

55.4 °F

Flash Point(C)

13 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Huiling Yuan et al.
Thorax, 65(4), 321-326 (2010-04-15)
15-S-Hydroxyeicosatetraenoic acid (15(S)-HETE) and 13-S-hydroxyoctadecadienoic acid (13(S)-HODE), both of which are metabolites of 15-lipoxygenases (15-LOXs), are endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARgamma). The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of
Eisaku Ogawa et al.
The Journal of investigative dermatology, 131(3), 604-612 (2010-11-12)
Fatty acid-binding proteins (FABPs) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. Epidermal FABP (E-FABP/FABP5) is predominantly expressed in keratinocytes and is overexpressed in the actively proliferating tissue characteristic

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