D5146
Diazolidinyl urea
≥95%
Synonym(s):
1-[1,3-Bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea, Diazolidinylurea, N-Hydroxymethyl-N-[1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-N′-hydroxymethylurea, N-[1,3-Bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N′-bis(hydroxymethyl)urea
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About This Item
Empirical Formula (Hill Notation):
C8H14N4O7
CAS Number:
Molecular Weight:
278.22
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O
InChI
1S/C8H14N4O7/c13-1-9-7(18)10(2-14)5-6(17)12(4-16)8(19)11(5)3-15/h5,13-16H,1-4H2,(H,9,18)
InChI key
SOROIESOUPGGFO-UHFFFAOYSA-N
General description
Diazolidinyl urea is urea derivative that is commonly used as a preservative and antimicrobial agent in cosmetics and personal care products.
Application
- Impact of cosmetic preservatives on skin cells: A study examined the effects of various cosmetic preservatives, including Diazolidinyl Urea, on healthy human skin cells, highlighting the cellular responses and potential implications for skin health (Głaz et al., 2023).
- Formaldehyde releasers in personal care: An extensive clinical review discussed allergic contact dermatitis caused by formaldehyde and formaldehyde releasers such as Diazolidinyl Urea, providing insights into allergic reactions and safety concerns in dermatological practice (Goossens and Aerts, 2022).
- Carcinogenic potential of cosmetic ingredients: Research on potential carcinogens in makeup cosmetics included Diazolidinyl Urea, emphasizing the safety and regulatory aspects concerning its use in cosmetic formulations (Balwierz et al., 2023).
- Patch testing for allergen sensitivity: A study integrated Diazolidinyl Urea in a patch test series to evaluate skin sensitization and allergic reactions in patients, aiding in the assessment of its allergenic potential (Bizjak et al., 2022).
Disclaimer
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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R O Williams et al.
Journal of chromatography. B, Biomedical sciences and applications, 696(2), 303-306 (1997-08-29)
A high-performance liquid chromatographic method for the determination of diazolidinyl urea (DU) in a cream formulation is described. The aqueous phase of the emulsion was separated by centrifugation, removed, filtered, diluted and applied onto the HPLC system. DU was detected
Claus Zachariae et al.
Contact dermatitis, 54(1), 21-24 (2006-01-24)
The morphology of early allergic contact dermatitis reactions was studied in formaldehyde allergic individuals exposed to a cream product preserved with 4 different concentrations of diazolidinyl urea. The study was made using a dose-escalating design in 3 different anatomical regions
A T Karlberg et al.
Contact dermatitis, 38(1), 20-28 (1998-03-21)
Reliable and uncomplicated methods for detection of free formaldehyde in products preserved with formaldehyde donors are desirable to decrease the risk of allergic contact dermatitis. The aim of this study was to develop a method that could be used in
Claus Zachariae et al.
Contact dermatitis, 53(5), 268-277 (2005-11-15)
The elicitation potential of the cosmetic preservative diazolidinyl urea was studied in formaldehyde- and diazolidinyl urea-sensitized volunteer patients using a stepwise controlled exposure design. The test product was a facial moisturizer, preserved with varying concentrations of diazolidinyl urea, ranging from
Takahiro Doi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(10), 1005-1010 (2009-03-10)
A new HPLC method for simultaneous measurement of diazolidinyl urea (DU), urea, and allantoin by hydrophilic interaction chromatography using a column packed with triazol-bonded silica particles is described. The calibration curves of DU, urea, and allantoin were linear over the
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