Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

341894

Sigma-Aldrich

Cyanogen bromide solution

3.0 M in methylene chloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
BrCN
CAS Number:
506-68-3
Molecular Weight:
105.92
Beilstein:
1697296
MDL number:
MFCD00011597
UNSPSC Code:
12352100
PubChem Substance ID:
24861007
NACRES:
NA.22

form

liquid

concentration

3.0 M in methylene chloride

solubility

alcohol: freely soluble
diethyl ether: freely soluble
water: freely soluble

density

1.443 g/mL at 25 °C

SMILES string

BrC#N

InChI

1S/CBrN/c2-1-3

InChI key

ATDGTVJJHBUTRL-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Cyanogen bromide solution induces template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines.Mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted morpholine buffers is investigated.

Application

Cyanogen bromide (CNBr) solution may be used in the cyanogen bromide method for covalent immobilization of trypsin onto poly(2-hydroxyethyl methacrylate)/ polystyrene composite microspheres. It may be used in the preparation of CNBr-activated diol-silica, useful as silica support in HPLC.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

EUH032

Storage Class Code

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Luis A Jurado et al.
Journal of chromatography. A, 971(1-2), 95-104 (2002-09-28)
To obtain silica supports for high-performance affinity chromatography, a method of preparing CNBr-activated diol-silica under anhydrous conditions was developed. Activation of the silane-derived hydroxyls with cyanogen bromide and triethylamine was optimized and demonstrated to efficiently couple several amino ligands (tryptophan
Z A Shabarova et al.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 27(5-6), 555-566 (2001-09-07)
Cyanogen bromide has been found to induce the template-guided condensation of oligonucleotides only in the presence of N-substituted morpholines. Based on 31P, 1H and 13C NMR spectroscopy data, the mechanism of the phosphomonoester group activation by cyanogen bromide in N-substituted
Covalent immobilization of trypsin onto poly (2-hydroxyethyl methacrylate)/polystyrene composite microspheres by cyanogen bromide method and its enzymatic activity.
Okubo M, et al.
Colloid and Polymer Science, 265(11), 957-964 (1987)
Bart Vanelslander et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(7), 2412-2417 (2012-02-07)
The spatial organization of biofilms is strongly regulated by chemical cues released by settling organisms. However, the exact nature of these interactions and the repertoire of chemical cues and signals that micro-organisms produce and exude in response to the presence
Deborah Negrão-Corrêa et al.
PloS one, 9(2), e88042-e88042 (2014-02-08)
Studies in murine models and human populations have indicated that the collagen-rich granulomatous response against parasite eggs trapped in the liver is associated with the development of severe hepatosplenic schistosomiasis, characterized by periportal fibrosis and portal hypertension. The role of
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service