PHR9070

Favipiravir

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• Synonym(e): 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide, Avigan, T-705, T705
• Empirische Formel (Hill-System): C₅H₄FN₃O₂
• CAS-Nummer: 259793-96-9
• Molekulargewicht: 157.10
• MDL-Nummer: MFCD12032148
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; TraceCERT^®
• Qualitätsniveau: 300
• Produktlinie: TraceCERT^®
• Form: solid
• Haltbarkeit: limited shelf life, expiry date on the label
• Hersteller/Markenname: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• Anwendung(en): pharmaceutical small molecule
• Lagertemp.: −20°C
• SMILES String: FC1=CNC(C(C(N)=O)=N1)=O
• InChI: 1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
• InChIKey: ZCGNOVWYSGBHAU-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

Biochem./physiol. Wirkung

Favipiravir (T-705) is an inhibitor of viral RNA polymerase. In cells, the comound is converted to T-705-4-ribofuranosyl-5-triphosphate, which selectively targets the viral polymerase without affecting mammalian RNA or DNA polymerases. Favipiravir inhibits replication of inluenza viruse A, B and C with IC50 values between 0.013 and 0.48 mM. The compound protects mice from lethal-dose infections of wild type and neuraminidase inhibitor-resistant strains of H5N1 viruses, Favipiravir has been found to have activity against many viruses including flavi-, alpha-, filo-, bunya-, arena-, noro-, and of other RNA viruses, and is already used off-label for Ebola and Lassa virus.

Empfohlene Produkte

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Rechtliche Hinweise

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• H-Sätze: H341,H361d
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Muta. 2 - Repr. 2
• Lagerklassenschlüssel: 4.1B - Flammable solid hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable