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Supelco

SUPELCOSIL™ LC-CN (5 µm) HPLC Columns

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonym(e):

MTO-SUPELCOSIL™ LC-CN 5UM 15CMX4.6MM HPLC SÄULE

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About This Item

UNSPSC-Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

SUPELCOSIL™ LC-CN HPLC-Säule, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

Materialien

stainless steel column

Agentur

suitable for USP L10

Produktlinie

SUPELCOSIL™

Leistungsmerkmale

endcapped

Verpackung

1 ea of

Kennzeichnungsgrad

4% Carbon loading

Parameter

≤70 °C temp. range

Methode(n)

HPLC: suitable

L × ID

15 cm × 4.6 mm

Oberflächenbereich

170 m2/g

Oberflächendeckung

surface coverage 3.5 μmol/m2

Matrix

silica gel, spherical particle platform
fully porous particle

Aktive Matrixgruppe

cyano phase

Partikelgröße

5 μm

Porengröße

120 Å

pH-Bereich

2-7.5

Trenntechnik

hydrophilic interaction (HILIC)
normal phase
reversed phase

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Allgemeine Beschreibung

Die LC-CN ist eine häufig verwendete Alternative zu Kieselgel, da sie die Vorteile einer gebundenen Phase bietet (schnelle Equilibrierung, geringe Empfindlichkeit bzgl. des Wassergehalts der mobilen Phase). Sehr oft wird die LC-CN auch mit wässrigen mobilen Phasen als RP-Säule verwendet.

Anwendung


  • Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: : This study presents a validated HPLC-UV method for monitoring mycophenolic acid in human plasma. The research highlights the necessity and efficiency of internal standardization in achieving accurate measurements. (Kunicki PK et al., 2021).

  • An Improved HPLC Method for Therapeutic Drug Monitoring of Daunorubicin, Idarubicin, Doxorubicin, Epirubicin, and Their 13-dihydro Metabolites in Human Plasma.: This paper describes an enhanced HPLC method for monitoring therapeutic levels of several chemotherapeutic agents and their metabolites in human plasma, improving the accuracy and reliability of drug monitoring. (Fogli S et al., 1999).

  • Analysis of Diltiazem and Desacetyldiltiazem in Serum by High-Performance Liquid Chromatography.: This research focuses on an HPLC method for analyzing diltiazem and its primary metabolite in serum, providing a robust tool for clinical pharmacokinetic studies. (Paczkowski D et al., 1995).

  • High-Performance Liquid Chromatographic Method for the Determination of Eclanamine and Its N-Desmethyl and N,N-Didesmethyl Metabolites in Urine.: The study details a high-performance liquid chromatographic method for determining eclanamine and its metabolites in urine, crucial for pharmacokinetic and toxicological analysis. (Lakings DB et al., 1988).

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Rechtliche Hinweise

SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC

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S Fogli et al.
Therapeutic drug monitoring, 21(3), 367-375 (1999-06-12)
A single high-performance liquid chromatography (HPLC) method, suitable for the analysis of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites is validated in the present study. Preparation of plasma samples was performed by a first extraction of analytes with a
H Kataoka et al.
Journal of chromatography. B, Biomedical sciences and applications, 731(2), 353-359 (1999-10-08)
The technique of automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) was evaluated for the determination of ranitidine. In-tube SPME is an extraction technique for organic compounds in aqueous samples, in which analytes are extracted
H Kataoka et al.
Journal of analytical toxicology, 24(4), 257-265 (2000-06-29)
A simple and rapid method for the determination of amphetamine, methamphetamine, and their 3,4-methylenedioxy derivatives in urine samples was developed using automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS). In-tube SPME is an extraction technique
D Paczkowski et al.
Polish journal of pharmacology, 47(5), 429-434 (1995-09-01)
This paper describes a simple high-performance liquid chromatographic (HPLC) method for the determination of diltiazem and desacetyldiltiazem in human serum. After basic methyl-tert-butyl ether extraction and back-extraction with hydrochloric acid, the drug and its metabolite was injected into a Supelcosil

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