T6330

THI

• Synonym(e): 2-ATHBI, 2-Acetyl-4-tetrahydroxybutyl Imidazole; 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone
• Empirische Formel (Hill-System): C₉H₁₄N₂O₅
• CAS-Nummer: 94944-70-4
• Molekulargewicht: 230.22
• MDL-Nummer: MFCD08752516
• UNSPSC-Code: 12352211
• PubChem Substanz-ID: 329826636
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Farbe: white to light brown
• Löslichkeit: DMSO: 2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI: 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
• InChIKey: CQSIXFHVGKMLGQ-BWZBUEFSSA-N

Beschreibung

Biochem./physiol. Wirkung

2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation.

THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.

Angaben zur Herstellung

THI is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable